Welcome to the database of experimentally supported miRNA targets on protein-coding transcripts!
The content of TarBase-v9.0 is exclusively experimentally supported and consists of interactions identified via high- or low-yield methods. Raw datasets produced by state-of-the-art interactome mapping methods (e.g., HITS-CLIP, PAR-CLIP, CLASH) were uniformly analyzed to maintain consistently high-quality standards, while miRNA targets verified via low-yield methods were amassed by means of manual article curation.
Extensive effort was made to cater to users a harmonized dataset. For annotation, the Ensembl and miRBase nomenclatures were utilized. Rich metadata regarding details on miRNA-gene interactions, experimental settings, as well as the respective publications complement each entry. Furthermore, TarBase interactions are interconnected with PubMed, Ensembl and miRBase.
Extensive effort was made to cater to users a harmonized dataset. For annotation, the Ensembl and miRBase nomenclatures were utilized. Rich metadata regarding details on miRNA-gene interactions, experimental settings, as well as the respective publications complement each entry. Furthermore, TarBase interactions are interconnected with PubMed, Ensembl and miRBase.
TarBase is also seamlessly inter-connected with more than 86 million in-silico identified miRNA targets that are available through DIANA-microT 2023 (https://dianalab.e-ce.uth.gr/microt_webserver) as an asset to further explore the miRNA-gene pairs of interest and add an extra layer of interaction confidence. Interactive, exploratory visualizations and advanced filtering options are also provided to the users.
The entire contents of TarBase-v9.0 are free and open to all users without any register or log-in requirements!
If you found TarBase helpful for your study, please consider citing our publication:
Giorgos Skoufos, Panos Kakoulidis, Spyros Tastsoglou, Elissavet Zacharopoulou, Vasiliki Kotsira, Marios Miliotis, Galatea Mavromati, Dimitris Grigoriadis, Maria Zioga, Angeliki Velli, Ioanna Koutou, Dimitra Karagkouni, Steve Stavropoulos, Filippos S Kardaras, Anna Lifousi, Eustathia Vavalou, Armen Ovsepian, Anargyros Skoulakis, Sotiris K Tasoulis, Spiros V Georgakopoulos, Vassilis P Plagianakos, Artemis G Hatzigeorgiou, TarBase-v9.0 extends experimentally supported miRNA–gene interactions to cell-types and virally encoded miRNAs, Nucleic Acids Research, 2023, DOI: https://doi.org/10.1093/nar/gkad1071
This research has been co‐financed by the European Regional Development Fund of the European Union and Greek national funds through the Operational Program Competitiveness, Entrepreneurship and Innovation, under the call RESEARCH – CREATE – INNOVATE (project code:T2EDK-00391).