Peryton constitutes a novel resource of experimentally supported microbe-disease associations, currently hosting more than 7,900 entries linking 43 diseases and 1,396 microorganisms. Peryton’s content is exclusively sustained by manual curation of biomedical articles. Importantly, diseases and microorganisms are provided in a systematic, standardized manner using reference resources to create database dictionaries. Information about the experimental design, study cohorts and the applied high- or low-throughput techniques are meticulously annotated and catered to users.
Peryton’s content in numbers:
2,918 gastrointestinal disease associations
4,065 cancer-related associations
869 neurodegenerative disorder associations
125 cardiovascular disease associations
1,718 entries providing information at species level or below
3,777 entries comparing a disease group against healthy individuals and 4,200 comparing disease states
Extensive details regarding bacterial abundance, the groups under study (including their sex ratio and their size) and article metadata are available for each entry. A number of functionalities are provided to enhance user experience and enable ingenious use of Peryton. One or more microorganisms and/or diseases can be queried at the same time. Advanced filtering options and direct text-based filtering of results enable refinement of returned information and the conducting of tailored queries suitable to different research questions. Results can be directly downloaded as tab-separated files for local storage and downstream analyses. Peryton also provides to users’ interactive visualizations to effectively capture different aspects of its content. Via Network graphs, Chord diagrams and Hierarchy Diagrams users can browse into the available content and perform observations about microbe-disease relationships using information from the latest relevant literature.
Peryton was published in the 2021 Nucleic Acids Research Database Issue.
Please cite:
Giorgos Skoufos, Filippos S. Kardaras, Athanasios Alexiou, Ioannis Kavakiotis, Anastasia Lambropoulou, Vasiliki Kotsira, Spyros Tastsoglou & Artemis G Hatzigeorgiou. Peryton: a manual collection of experimentally supported microbe-disease associations (Nucleic Acids Research, Volume 49, Issue D1, 8 January 2021, Pages D1328–D1333, DOI:10.1093/nar/gkaa902)
The “ELIXIR-GR: Managing and Analysing Life Sciences Data (MIS: 5002780)” Project is co-financed by Greece and the European Union - European Regional Development Fund